Author  
Place of duty  
Title   한국 여성에서 p21WAF1/Cip1 코돈 31 다형성과 자궁경부암 감수성 및 예후와의 연관성 ( p21WAF1/CIP1 Codon 31 Polymorphism in Korean Women : Association with Cervical Cancer Susceptibility and Prognosis )
Publicationinfo   2000 Jan; 032(06): 1050-1059.
Key_word   p21WAF1/Cip1, Polymorphism, Cervical neoplasm
Full-Text  
Abstract   Purpose: The aim of this study was to determine whether certain genotype of P21waf1/Cip1 might be associated with risk of cervical cancer in Korean women. Materials and Methods: We used the specimens derived from cervical cancer (n=111) composed of two histologic groups; SCCA (n=67) and adenocarcinoma (n=44), CIN III (n=101) and controls (n=98). For the determination of P2i WAF1/Cip1 polymorphism, DNA was examined by PCR-RFLP using BsmAI. We compared the distribution of P21WAF1/Cip1 genotype of Korean women with that of other ethnic groups and analyzed the distribution of invasive cancer, CIN III and controls. Results: The genotype frequency of controls was different from that of Caucasian and Chinese (p<0.001) but similar to that of Japanese (p=0.21). There was no difference in the genotype frequency of p21WAF1/Cip1 among SCCA, CIN III and controls (p > 0.05). A significant increase of Ser/Ser genotype was found in adenocarcinoma patients with high-risk HPV compared with the controls (p=0.009). The OR was 3.59, 95% CI=1.55~8.31, when comparing that group with controls. However, we could not find differences of prognosis. Conclusion: We found that codon 31 Ser/Ser homozygote of the p21WAF1/Cip1 would be a risk factor for the adenocarcinoma of cervix associated with high-risk HPV in Korean women.
저 자   김재원(Jae Weon Kim),노주원(Ju Won Roh),박노현(Noh Hyun Park),송용상(Yong Sang Song),강순범(Soon Beom Kang),이효표(Hyo Pyo Lee),김경선(Kyung Sun Kim),김문홍(Moon Hong Kim),정현훈(Hyun Hoon Chung)